At the end of this course, you will be able to:
• learn about the biology and the replicative cycle of viruses associated with cancers
• know the mechanism of tumorigenesis induced by these viruses
• understand the role of the immune system in controlling these viruses and the induced tumors
• be at the cutting edge of new advances in terms of vaccination and anti-tumor therapies.
About 20% of human cancers are induced by viruses, particularly in low/middle income countries, to a point that in some regions of the world, viral infection is the main etiology of human cancers. Our understanding of the relationship between viral infection and oncogenesis has considerably improved during the last two decades. As obligatory intracellular parasites, viruses encode proteins that reprogram host cellular signaling pathways that control proliferation, differentiation, cell death, genomic integrity, and recognition by the immune system. Both DNA and RNA viruses have been linked with human cancers.
Epstein-Barr virus, papillomaviruses, hepatitis B virus, human herpesvirus-8 and Merkel cell polyomavirus are the five DNA viruses that are capable of causing the development of human cancers. Human T lymphotrophic virus type 1 and hepatitis C virus are the two RNA viruses that contribute to human cancers. Treatment and prevention strategies critically depend on the double understanding of the mechanism of cell tumorigenesis and the way they are influenced by viruses.
During this MOOC, we will review the different mechanisms of virus induced carcinogenesis, from direct integration of the virus in the genome to non-specific inflammation and immune disorders. The epidemiology and specificity of each type of virus and of the induced tumor will then be given in detail. At the end we will report innovations in the prevention of virus induced tumors.
This MOOC is organized in 7 chapters :
1. Mechanisms of virus-induced oncogenesis: direct
2. Mechanisms of virus-induced oncogenesis: indirect
5. Hepatitis B and C viruses and hepatocellular carcinoma
6. Herpes viruses
7. Prevention and vaccination
Each chapter is composed of 2 to 6 sessions. In each session, you will find a 8 to12-minute video and a multiple choice test to help you check your understanding. The videos are in English and are subtitled in French and in English.
TWe recommend a good scientific background (such as a bachelor of science).
Chapter 1 : Mechanisms of virus induced oncogenesis : direct
Chapter 2: Mechanisms of virus induced oncogeneis: indirect
Chapter 3 :Retroviruses
Chapter 4: Papillomaviruses
Chapter 5 : Hepatitis B and C viruses and hepatocellular carcinoma
Chapter 6 : Herpes viruses/Virus de l’herpès
Chapter 7 : Prevention and vaccination
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