At the end of this course, you will be able to:
Tuberculosis has been a scourge of humanity for hundreds of years. In the 18th and 19th centuries, tuberculosis was called the white plague and in some countries in Europe and the US was responsible for 20% or more of all deaths. Today, out of all infectious agents, tuberculosis remains the biggest killer, surpassing even HIV and malaria. In 2015, according to WHO, there were nearly 10.4 million new cases of tuberculosis and around 1.8 million people died from the disease, making it one of the top 10 causes of deaths worldwide.
Although there are plans to eliminate it within the next couple of decades, the incidence is currently only falling by about 1.5% per year. Part of the problem is the nature of the disease, which takes months to develop and requires months of multi-drug chemotherapy to cure. It can also stay latent for decades and then emerge to cause serious illness. Another problem, this one man-made, is the drug resistance and multi-drug resistance that make TB much harder to cure.
To provide an up-to-date overview of the disease, the Institut Pasteur has created a MOOC dedicated to Tuberculosis. This course will provide a knowledge base that goes from the basics of TB to the current state of knowledge on various aspects of tuberculosis: the clinical picture, epidemiology, pediatric TB, factors affecting susceptibility to the disease, including HIV, diabetes and human genetics, immunology, vaccines, diagnosis, current and future ways to detect drug resistance, and how to treat drug sensitive and multi-drug resistant strains. It will also discuss clinically important non-tuberculous mycobacterial infections and how to diagnose and treat them. It will present recent advances in molecular techniques for diagnosis and drug sensitivity testing, including Whole Genome Sequencing, and the new, shorter and more effective treatment regimens to cure Multi-Drug Resistant TB.
The course aims at providing a broad overview of the current state of knowledge about tuberculosis for physicians, nurses and other health and public health workers, microbiologists, pharmacists, researchers and students. It will serve as a valuable update for people working with tuberculosis, a thorough introduction for those who are new to the field and a great opportunity for all those who want to broaden their understanding of the disease.
This MOOC is organized in 6 weeks. Each week is composed of 4 to 6 sequences. In each sequence, you find a 10 minute video and two multiple choice questions (MCQ) to help students check their understanding. The videos are in English subtitled in French and in English. All the tests are in English. A weekly evaluation is performed using about 10 MCQs and, at the end of the course, a final evaluation is performed with 30 MCQs.
This MOOC is aimed at people interested in Tuberculosis: microbiologists, researchers in infectious diseases, biologists, physicians, epidemiologists, public health workers and patient education, as well as students in any of these areas.
A bachelor of science, a degree in a health related field or a good scientific background is recommended to be able to participate in this MOOC.
Weekly tests plus a final QCM test will allow obtaining a certification of successful attending to the course.
Week 1: Introduction and TB Epidemiology
Week 2: TB Immunology
Week 3: TB genomes: evolution, molecular epidemiology, drug resistance
Week 4: Drug Resistance
Week 5: Treatment
Week 6: Future Approaches and Challenges
You are free to:
Under the following terms: