Resistance to bacterial agents
Ref. 96009
- Duration: 8 weeks
- Effort: 20 hours
- Pace: ~2h30/week
No open course runs
Description
In 2016, the "review on antimicrobial resistance", chaired by Jim O'Neill, estimated that without action, in 2050, 10 million people a year could die from drug-resistant infections. While this figure is hypothetical, the current situation led WHO to classify the emergence and spread of antibacterial agents as an "increasingly serious threat to global public health that requires action across all government sectors and society."
The MOOC "Resistance to antibacterial agents" addresses the major public health problem: of the emergence of multidrug-resistant bacteria isolates, which are responsible for an increase in the morbidity and mortality of a wide range of infections caused by bacteria.
In this course, we intend to provide basic knowledge regarding resistance to antibacterial agents. We address key questions in the field. This MOOC will first present different antibacterial agents and their use for animals and humans. It will describe the current epidemiological landscape of antibiotic resistance across the globe and explain how the resistance is detected in the medical laboratories. The MOOC will then present the origins of antibiotic resistance and its mechanisms of dissemination, before proposing different approaches to control its spread. Finally, this MOOC will highlight the alternatives to antibiotics, the most current molecules in use, and ongoing novel molecule development.
Format
The MOOC is organized in 6 weeks. Each week is composed of 4 to 5 sections. Each section includes an 8-to-10-minute video and 2 multiple-choice questions to help participants test their acquired knowledge. The videos are in English, with French and English subtitles. All the tests are in English
Prerequisites
This MOOC is aimed at undergraduate, graduate and PhD biology students, medical doctors, teachers, researchers and all those who want to learn how antibacterial agents work and how resistant strains have emerged and disseminated. A good scientific background is recommended to follow this MOOC.
Assessment and certification
This MOOC also offers a weekly evaluation, with about 10 multiple-choice questions (MCQs) and, at the end of the course, a final evaluation, with 30 MCQs.
Course plan
- Week 1: Antibacterial agents
- Mode of action
- Origin and biosynthesis
- Impact on Human Health
- Antibiotherapy
- Veterinary use
- Week 2: Emergence of resistant bacteria
- Resistance Mechanisms
- Antibacterial resistance in the community and the hospital
- Epidemiology of Bacterial Resistance in Europe
- Bacterial resistance in low- and middle-income countries countries
- Week 3: Detection of resistant bacteria
- Phenotypic approaches
- Genotypic approaches
- In silico antibiogram: Genomic approaches
- Automated approaches
- Week 4: Origin of antibiotic resistance and dissemination
- Natural versus Acquired Resistance
- Origin of resistance genes
- Role of the environment
- Transferability of resistance genes
- Evolution of bacterial populations
- Week 5: Controlling the emergence and spread of bacterial resistance
- Consumption and Inappropriate use of antibiotics
- Antibiotics stewardship
- Mastering resistance in hospitals
- Economic cost of ABR
- Social consequences of bacterial resistance
- Week 6: New antibiotics and alternatives to antibiotics
- Revisiting "old" molecules
- New targets : from leads to candidate
- Anti-virulence Strategies
- Phagotherapy
- CRISPR tools to study and fight antibiotic resistance
Course runs
Archived
- From May 14, 2018 to June 25, 2018
- From Jan. 11, 2021 to March 10, 2021
Course team
Patrick Trieu-Cuot
Categories
Head of the "Biology of Gram-positive pathogens" Research Unit, Institut Pasteur.
Béatrice Berçot
Categories
Head of the Clinical Bacteriology Laboratory of the St Louis Hospital, Paris.
Organizations
License
License for the course content
Attribution-NonCommercial-NoDerivatives
You are free to:
- Share — copy and redistribute the material in any medium or format
Under the following terms:
- Attribution — You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.
- NonCommercial — You may not use the material for commercial purposes.
- NoDerivatives — If you remix, transform, or build upon the material, you may not distribute the modified material.
License for the content created by course participants
All rights reserved
"All rights reserved" is a copyright formality indicating that the copyright holder reserves, or holds for its own use, all the rights provided by copyright law.