Vaccines are among the most effective public health interventions currently available. Smallpox has been eradicated and polio has almost disappeared worldwide through global vaccine campaigns. Most of the viral and bacterial infections that traditionally affected children have been drastically reduced thanks to national immunization programs in developed countries. Together with antibiotics and clean water, vaccines have increased life expectancy in both high- and low-income countries by eliminating many of the diseases that historically killed millions. It has been estimated that vaccines will have saved ~25 million deaths over 10 yr from 2010 to 2020, which is equivalent to five lives saved per minute. In terms of cost-effectiveness, it is estimated that $1 invested in vaccination results in a $10–44 healthcare saving.
In spite of the success of vaccination in preventing disease and its cost-effectiveness, several challenges remain such as increasing the diversity of the target populations by developing vaccines efficient in pregnant women who will protect their babies at early life, and in the elderly displaying a less efficient immune system to be primed. Besides preventing infectious diseases, a few examples of already available vaccines preventing virus-induced cancers, such as liver cancer due to the hepatitis B virus or cervical cancers due to papilloma viruses, pave the way for further development of anti-cancer vaccines. Recent advances in technology to identify the key antigens to induce efficient protective immunity and large-scale analysis of human immune responses offer to revisit the future of vaccine development in a more global health perspective, taking also into consideration the implementation of new sustainable models for the developing world. This course aims at covering all these aspects to give an overview of the discipline.
To follow this course, you have the choice between two formulas: DISCOVERY formula which will allow you to familiarize yourself with the subject thanks to videos, quizzes and access to forums and QUALIFYING formula in which you can acquire skills and deep knowledge on the subjects.
If you opt for this formula, you will have access to the videos of the course, the quizzes and the exchanges in the forums. This route will not give rise to the issue of a certificate. Registrations are possible now and are not subject to any conditions.This registration is free.
In addition to the activities offered in the DISCOVERY formula, the QUALIFYING formula will allow you to obtain a certificate in the form of a "certificate". To do this, you will have to take a final individual exam, monitored remotely, lasting 1 hour, consisting of 30 multiple choice questions (MCQ) and obtaining 20 correct answers. You will also have access to hangouts.
The registration fee for the qualifying course is 150€.
Obtaining a qualifying certification is an opportunity for you to obtain a diploma. This course is one of the MOOCs of the Institut Pasteur's Digital Diploma in Infectious Diseases program (DNM2IP). For more information, see the Institut Pasteur web page, dedicated to this new diploma.
We recommend a good scientific background (such as a bachelor of science)
Please note that the "Qualifying" formula gives the right to a qualifying certification delivered by the Institut Pasteur. There will be no successful follow-up certificate, neither for the "Discovery" formula, nor for the "Qualifying" formula.
Chapter 1 – Introduction to vaccinology, an integrative discipline- part 1
Chapter 2 – Introduction to vaccinology, an integrative discipline- part 2
Chapter 3 - Preclinical and clinical steps: Basic principles
Chapter 4 - Update of vaccine development for the major infectious diseases
Chapter 5 - Vaccines remaining to be developed and implemented
Chapter 6 - Future challenges
You are free to:
Under the following terms: