Innate Immunity

What you will learn

At the end of this course, you will be able to:

Define the cellular and molecular players of innate immunity,
Describe the mechanisms that lead to the elimination of pathogens
Explain the strategies of the pathogens against the innate immune system
Discuss the influence of genetic and microbiota on innate immune system
Present its links with central nervous system and adaptive immunity

Description

Innate immunity acts as a first line of defense and can destroy invading microorganisms and trigger inflammation that contributes to blocking their assault, days before the action of adaptive immunity. While adative immunity was the major focus of researchers in the XXth century, the sensing of the exogenous or endogenous dangers signals was recently described, as well of the action of numerous cells. This MOOC describes the players and the whole orchestra involved in innate immunity against pathogens.

Format

The MOOC is organized into 6 chapters. Each chapter has 1 to 8 sessions. In each session, you will find an 8 to 15 minute video and a multiple choice question test to help you check your understanding. There are 2 to 16 multiple choice questions at the end of each chapter depending on the number of sessions and a certification exam.

The videos are in English, with English and French subtitles.

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Prerequisites

A good scientific level is recommended to follow this MOOC (Bachelor in life sciences studies).

This MOOC targets people with a medical or scientific training background who are interested in all aspects of innate immunity: medical students, scientific Master II and PhD students (Immunology, Bacteriology, Parasitology, Virology…), post-doc, physicians, pharmacists, veterinarians, and all scientists working on bacteria, viruses, fungi and parasites, interested to learn more about the defense mechanism of the host against their favored bug.

Assessment and certification

To follow this course, you can choose between two options:

- The Discovery Course gives access to videos, quizzes and discussions in the forum. No certificate is issued for this course. Registration is free.

- The Qualifying Course leads to a certificate. In addition to the activities of the Discovery Course, you will have to take a one-hour supervised distance learning exam, consisting of 30 multiple-choice questions (MCQs) and obtaining 18 correct answers. The registration fee for the Qualifying Course is 150€.

Successful completion of the Qualifying Course gives you the opportunity to apply for the Institut Pasteur Online Diploma of Infectious Diseases (DNM2IP), which consists of 5 certificates to Institut Pasteur MOOCs on infectious diseases. To learn more, visit the Institut Pasteur's web page dedicated to this diploma.

To qualifying path, success at this final examination will provide you with a certificate signed by FUN and by Institut Pasteur.

Course plan

- C1.1 : Macrophages // Jean-Marc Cavaillon
  C1.2 : Polymorphonuclear Neutrophils // Margarita Hurtado-Nedelec
  C1.3 : NK Cells // Daniel Scott-Algara
  C1.4 : Invariant Natural Killer T (iNKT) cells: an innate-like T cell population // Maria Leite-de-Moraes
  C1.5 : Innate Lymphoid Cells // Gérard Eberl
- C2.1 : gdT lymphocytes : what are they and how do they respond to pathogens? // Julie Déchanet-Merville
  C2.2 : Th17 cells // Pierre Miossec
  C2.3 : RegulatoryT cells // Laurence Weiss
  C2.4 : Dendritic cells // Anne Hosmalin
  C2.5 : Mast cells: Critical Regulators of Immunity to Pathogens and Toxins // Salah Mecheri
- C3.1 : Pathogen associated molecular patterns // Jean-Marc Cavaillon
  C3.2 : DAMPs (alarmins) // Lionel Apetoh
  C3.3 : Pattern recognition receptors: toll-likereceptors // Jean-Marc Cavaillon
  C3.4 : PRRs: Nod-LikeReceptors (NLR) // Catherine Werts
  C3.5 : PRRs: Rig-LikeReceptors (RLR) // Eliane Meurs
- C4.1 : The complement system // Lubka Roumenina
  C4.2 : Cytokines // Jean-Marc Cavaillon
  C4.3 : Chemokines // Christophe Combadiere
  C4.4 : Antimicrobial Peptides // Maria Luisa Mangoni
- 5.1 : Anti-infectious role of cytokines // Jean-Marc Cavaillon
  5.2 : Innate immunity and bacterial infection // Makram Essafi
  5.3 : Toll-like receptors (TLRs) in influenza virus infection // Suki Lee
  5.4 : Innate immunity against fungal infection // Oumaïma Ibrahim-Granet
  5.5 : Inhibition of innate immunity by vaccinia virus // Geoffrey L Smith
  5.6 : Mucosal innate immunity // Jean-Claude Sirard
- 6.1 : Sepsis: an overwhelmed innate immune response // Jean-Marc Cavaillon
  6.2 : Influence of microbiota on innate immunity // Ivo G. Boneca
  6.3 : Regulation of the immune system by the central and peripheral nervous system // Monique Lafon
  6.4 : Links between innate and adaptive immunity // Claude Leclerc
  6.5 : Evolutionary Genetics of the Human Innate Immune System // Lluis Quintana-Murci
  6.6 : Trained innate immunity // Jessica Quintin
  6.7 : Parameters influencing the immune response // Jean-Marc Cavaillon

Organizations

Institut Pasteur

Social networks

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License

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