Description
More than a century ago, Elie Metchnikoff established the bases of cellular innate immunity when he discovered the mechanism of phagocytosis.
However, during most of the XXth century, adaptive immunity (also known as specific immunity) focused most of the interest of the researchers, until Charles Janeway and Polly Matzinger revisited the definition of immunology.
What was called “non-specific immunity” was renamed “innate immunity”, and the understanding of the sensing of the exogenous or endogenous dangers signals, and their identification revolutionized our understanding of the early mechanism aimed to defend the integrity of the host against any type of attacks including pathogens.
Nowadays, how bacteria, viruses, parasites and fungi are sensed by the infected host, have been mostly deciphered. Similarly, the mechanisms of the host involved to defend its integrity against infectious process have been decoded. This MOOC describes the players and the whole orchestra involved in innate immunity against pathogens.
Format
This MOOC is organized in 6 weeks. Each sequence is composed of 4 to 7 sequences. In each sequence, you find a 10 minute video and a multiple choice test to help students check their understanding. The videos are in English subtitled in French and in English.
You may register to this MOOC in two ways:
Discovery path.
You get access to all video-sessions, post session and weekly quizzes and web-forum.
Qualifying path.
In addition to video-sessions, post session and weekly quizzes and web-forum, you have access to hangouts along the MOOC and to a final individual online evaluation under surveillance.
Success at this final examination will provide you with a certificate signed by FUN and by Institut Pasteur.
The cost of the qualifying course is 150€.
Before registering to the qualifying path make sure that your scientific background is sufficient enough and correspond at least to a bachelor of live sciences.
Prerequisites
This MOOC targets people with a medical or scientific training background who are interested in all aspects of innate immunity: medical students, scientific Master II and PhD students (Immunology, Bacteriology, Parasitology, Virology…), post-doc, physicians, pharmacists, veterinarians, and all scientists working on bacteria, viruses, fungi and parasites, interested to learn more about the defense mechanism of the host against their favored bug.
Ce MOOC vise les personnes qui possèdent des connaissances dans le domaine médical ou scientifique ou étudient ce domaine, et s’intéressent à tous les aspects de l’immunité innée ; étudiants en médecine, étudiants en deuxième année de master ou doctorants pour un diplôme en sciences (immunologie, bactériologie, parasitologie, virologie…), les post-doc, les médecins, les pharmaciens, les vétérinaires et tous les scientifiques qui travaillent sur les bactéries, les virus, les champignons et parasites. Ainsi que pour tous ceux qui souhaitent mieux comprendre le mécanisme de défense de l’hôte contre les pathogènes.
Assessment and certification
To qualifying path, success at this final examination will provide you with a certificate signed by FUN and by Institut Pasteur.
Course plan
- Week 1: Cellular players - part 1
- Macrophages
- Neutrophils
- NK cells
- NKT cells
- Innate lymphoid cells
- Week 2: Cellular players - part 2
- T γ/δ lymphocytes
- Th17 lymphocytes
- Treg lymphocytes
- Dentritic cells
- Mast cells
- Week 3: Molecular players - part 1
- PAMPs / Pathogen associated molecular patterns (PAMPs)
- DAMPs (alarmins) / Damage associated molecular patterns (DAMPs)
- PRRs : TLR / Pattern recognition receptors (PRRs)
- PRRs : NLR / Pattern recognition receptors (PRRs)
- PRRs : RLR / Pattern recognition receptors (PRRs)
- Week 4: Molecular players - part 2
- The complement system
- Cytokines
- Chemokines
- Anti-microbial peptides
- Week 5: Host-pathogen interactions
- Anti-infectious role of cytokines
- Innate immunity and bacterial infection
- Innate immunity and viral infection
- Innate immunity and parasitic infection
- Innate immunity against fungal infection
- Microbial strategies against the immune system
- Mucosal innate immunity
- Week 6: Regulation of innate immune response
- Sepsis/ an overwhelmed innate immune response
- Influence of microbiota on innate immunity
- Regulation of the immune system by the central and peripheral nervous system
- Links between innate and adaptive immunity
- Trained innate immunity
- Parameters influencing immune responses
Other course runs
Archived
- From Nov. 4, 2019 to May 1, 2020
- From May 2, 2017 to June 12, 2017
Course team
Jean-Marc Cavaillon
Daniel Scott-Algara
Organizations
License
License for the course content
Attribution-NonCommercial-NoDerivatives
You are free to:
- Share — copy and redistribute the material in any medium or format
Under the following terms:
- Attribution — You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.
- NonCommercial — You may not use the material for commercial purposes.
- NoDerivatives — If you remix, transform, or build upon the material, you may not distribute the modified material.
License for the content created by course participants
All rights reserved
"All rights reserved" is a copyright formality indicating that the copyright holder reserves, or holds for its own use, all the rights provided by copyright law.
