Stem cells have the spectacular ability to restore the function of damaged tissues, providing major opportunities for fundamental studies on organogenesis, regeneration, diseases, and ageing. In spite of intense research in this field, many unanswered questions remain regarding stem cell regulation and function.
The Advances in Stem Cell Biology MOOC was created to provide an overview of stem cell biology, the properties of stem cells and their potential in directing organogenesis and regeneration in different organisms, and how they can be exploited for therapeutic purposes.
During this MOOC you will learn about the characteristics and properties of stem cells, along with the latest discoveries in the field from general concepts to different categories of stem cells, and how they participate in organogenesis in the organism - and in vitro.
This MOOC is organized in 5 chapters of 2 to 10 sessions each. Each session includes a short video and 2 multiple choice questions in english to help you test your understanding. There are 4 to 20 multiple choice questions at the end of each chapter. A certification exam (in English) is accessible only for students registered to the “qualifying path”. The videos are in English, subtitles in English and French are provided.
We recommend a good scientific background (such as a bachelor of life science)
This MOOC aims to reach anybody who wishes to learn more about emerging viruses and pandemics, whether scientist, medical doctor or other health workers, staff of governmental and non-governmental agencies or students in life sciences.
Assessment and certification
To follow this course, you have the choice between two formulas: DISCOVERY formula which will allow you to familiarize yourself with the subject thanks to videos, quizzes and access to forums and QUALIFYING formula in which you can acquire skills and deep knowledge on the subjects.
If you opt for this formula, you will have access to the videos of the course, the quizzes and the exchanges in the forums. This route will not give rise to the issue of a certificate. Registrations are possible now and are not subject to any conditions. This registration is free.
In addition to the activities offered in the DISCOVERY formula, the QUALIFYING formula will allow you to obtain a certificate in the form of a "certificate". To do this, you will have to take a final individual exam, monitored remotely, lasting 1 hour, consisting of 30 multiple choice questions (MCQ) and obtaining 20 correct answers. You will also have access to hangouts.
The registration fee for the qualifying course is 150€.
Please note, only the "Qualifying" formula gives the right to a qualifying certification issued by Fun and the Institut Pasteur. In addition, there will be no certificate of successful follow-up, neither for the "Discovery" formula, nor for the "Qualifying" formula.
- W1-1: What are Stem cells
W1-2: What defines the fate of stem cells ?
W1-3: Introduction to asymmetric cell division
W1-4: Asymmetric cell division: the cellular and molecular processes
- Chapter 5: Stem cell applications
- W2-1: Intestinal stem cells
W2-2: Drosophila Intestinal Stem Cells
W2-3: Introduction to Hematopoietic stem cells
W2-4: Origins of hematopoietic stem cells
W2-5: Tracking the journey of hematopoietic stem cells in live zebrafish embryos
W2-6: Neural Stem cells
W2-7: Skeletal muscle identity
W2-8: Skeletal muscle stem cell properties and ageing
W2-9: Deconstructing and reconstructing a satellite cell niche
W2-10: Heart regeneration
- W3-1: Human pluripotent stem cell derivation
W3-2: What are the most common methods to generate iPSCs ?
W3-3: Specification and segregation of embryonic vs. extra-embryonic stem cells
W3-4: Differentiation of ICM cells: the underlying mechanisms
W3-5: Derivation of mouse embryonic stem cells
W3-6: Derivation of human embryonic stem cells
- W4-1: Using ES cells to understand how cells build organisms
W4-2: Self-organization of embryonic organoids
- W5-1: Intestinal cancer stem cells
W5-2: The bioethics of stem cell research and therapy
Other course runs
- From April 27, 2020 to June 23, 2020
With the participation of
Shahragim Tajbakhsh (Institut Pasteur, France), François Schweisguth (Institut Pasteur, France), Marc Van de Wetering (Princess Maxima Center for Pediatric Oncology, Netherlands), Allison Bardin (Institut Curie, France), Ana Cumano (Institut Pasteur, France), Philippe Herbomel (Institut Pasteur, France), Pierre-Marie Lledo (Institut Pasteur, France), Matthias Lutolf (EPFL, Switzerland), Sigolène Meilhac (Institut Pasteur, Institut Imagine, France) Laurence Daheron (Harvard Stem Cell Institute, USA), Kat Hadjantonakis (Sloan Kettering Institute, USA), Jenny Nichols (Cambridge Stem Cell Institute, UK), Alfonso Martinez Arias (University of Cambridge, UK), Emmanuelle Rial-Sebbag (Inserm, France)
This MOOC was created by the Education Department of the Institut Pasteur.
This MOOC was realized with the support of the Fondation IPSEN, under the eagis of Fondation de France.
This MOOC was realized with the support of the LaBex REVIVE.