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  • Advanced NMR Spectroscopy

Advanced NMR Spectroscopy

Ref. 54010
CategoryPhysics and chemistry
  • Duration: 6 weeks
  • Effort: 24 hours
  • Pace: ~4 hours/week
Going further into NMR experiments !
No open course runs

What you will learn

At the end of this course, you will be able to:

  • understand how liquid-state NMR experiments work and can be applied to analyze biological macromolecules and mixtures of metabolites, 
  • discover the principles to acquire MRI images.

Description

The NMR phenomenon is widely used in MRI to form pictures of our organs and tissues. NMR spectroscopy is also a key tool to analyze biological molecules, such as proteins and carbohydrates, as well as complex biological or chemical mixtures in metabolomics approaches.

“Advanced NMR spectroscopy” is the second course of a comprehensive three-part online learning program on NMR. It aims at providing the participants with advanced knowledge about NMR. In particular, it presents tools and concepts such as product operators, coherence selection, and relaxation needed to understand how NMR techniques work, as well as specific techniques used to analyze particular samples, such as proteins, carbohydrates and mixtures of metabolites, or to acquire MRI images.

This course is intended for undergraduate and graduate students as well as educators and professionals who wish to deepen their understanding of NMR experiments.

Format

During the six weeks of the MOOC you will learn theoretical principles and experimental techniques to understand NMR experiments, through video lectures as well as discussions with other participants and professors through the discussion forum.
This MOOC is taught in English.
However, subtitles in simplified Chinese and Japanese are also provided.

Prerequisites

The participants should have some basic knowledge of NMR spectroscopy and its application for small organic molecules in solution.

Assessment and certification

We remind you that no attestation of achievement nor open badge no certificate for this course will be delivered at the end of the course.

Course plan

  • Week 1: Operator description of NMR
  • Week 2: Relaxation
  • Week 3: Coherence selection
  • Week 4: Protein NMR
  • Week 5: Practical course and NMR metabolomics
  • Week 6: NMR of glycans and MRI

Course runs

Archived

  • From Nov. 2, 2021 to Dec. 20, 2021
  • From Sept. 19, 2022 to Feb. 28, 2023

Course team

Olivier Lafon

Categories

Dr. Olivier Lafon is a professor at the University of Lille. The focus of his research is to push the frontiers of solid-state NMR spectroscopy in order to gain unique insights into the structure-property relationships of materials used in the fields of bio-economy, energy and health. His current research interests include the development of novel solid-state NMR methods, notably at high magnetic fields, for quadrupolar nuclei or using Dynamic Nuclear Polarization (DNP), as well as their application for the characterization of materials, including heterogeneous catalysts, porous materials and energy materials. Olivier Lafon received a B.Sc. in physical chemistry from the Ecole Normale Supérieure de Lyon. He obtained MS and PhD degrees from the University of Paris South. He was awarded the Magnetic Resonance in Chemistry Award for Young Scientists by the Euromar scientific committee and became a fellow of the Institut Universitaire de France in 2016. He is the chief science officer of the Lille high-field NMR facility, part of the INFRANALYTICS research infrastructure, and the coordinator of the project to install a 1.2 GHz NMR spectrometer in Lille. He is also a member of the editorial board of the journal Solid-State Nuclear Magnetic Resonance.

Robert Schneider

Categories

Dr. Robert Schneider studied biology and physics in Munich (Germany) and Cambridge (USA). During his Ph.D. thesis at the Max Planck Institute for Biophysical Chemistry in Göttingen (Germany), he applied solid-state NMR spectroscopy to membrane and fibrillar proteins. His work led to a structural model of the inactivated state of a potassium channel as well as of fibrils formed by polyglutamine peptides. As a postdoctoral researcher at the Institut de Biologie Structurale in Grenoble (France), he studied interactions of intrinsically disordered proteins in kinetic detail using solution-state NMR. He has held a position as assistant professor at the University of Lille since 2014, where he continued to study membrane and disordered proteins using NMR spectroscopy in solution and in the solid state. In April 2021, he has taken a position as NMR application scientist with Bruker Biospin in Fällanden (Switzerland).

Patrick Giraudeau

Categories

Dr. Patrick Giraudeau is a professor of analytical chemistry at the University of Nantes. His research activities at the CEISAM Research Institute are focused on the development of quantitative NMR methods for the analysis of complex mixtures, including applications to metabolomics and fluxomics. Highlights include the development of fast multidimensional quantitative experiments at high fields and also on benchtop spectrometers as well as recent investigations in dissolution dynamic nuclear polarization. He received his Ph.D. degree in Nantes in 2008, then he worked as a postdoctoral researcher at the Weizmann Institute of Science (Israel). In 2009, he became an Associate Professor at the University of Nantes, where he became a Full Professor in 2017. In 2014, he became a fellow of the Institut Universitaire de France and received a consolidator grant from the European Research Council in 2018. He is an associate editor of Magnetic Resonance in Chemistry, the vice-president of the French Metabolomics and Fluxomics Network (RFMF), and the head of the CEISAM-Corsaire-MetaboHUB NMR facility.

Luisa Ciobanu

Categories

Dr. Luisa Ciobanu is a neurophysicist who focuses on the development of ultra-high field magnetic resonance imaging (UHF-MRI) techniques for the understanding of the fundamental physical principles underlying biological function. Dr. Ciobanu received her doctorate in physics from Ohio State University in 2002. She then went on to do post-doctoral training in the Department of Electrical and Computer Engineering at University of Illinois at Urbana Champaign. After her postdoc, she has held research appointments at the Beckman Institute, University of Illinois at Urbana-Champaign and Pfizer, Inc. (Michigan, Ann Arbor). In 2007, she joined NeuroSpin at CEA-Saclay, France, where she heads the NeuroPhysics team.

Yann Guérardel

Categories

Dr. Yann Guérardel is a biochemist whose research focuses on structure-to-function relationships of complex glycoconjugates in different biological contexts including host-parasite interactions and human diseases. He obtained a PhD in biochemistry at Lille University and conducted post-doctoral trainings in Academia Sinica of Taipei (Taiwan) and in Nagoya University (Japan) to develop the use of high-field liquid-state NMR and mass spectrometry for the structural analysis of carbohydrates. He is presently senior researcher at the CNRS, acts as Director of the Institute for Structural and Functional Glycobiology (UGSF, UMR CNRS 8576) and is associate professor at iGCORE, Gifu University, Japan.

Organizations

University of Lille

Acknowledgements

Dr. Ming Shen, associate professor at East China Normal University, P. R. China and Dr. Akiko Sasaki, researcher at Bruker BioSpin, Japan are acknowledged for the translation of the subtitles into simplified Chinese and Japanese, respectively.

License

License for the course content

Attribution-NonCommercial-NoDerivatives

You are free to:

  • Share — copy and redistribute the material in any medium or format

Under the following terms:

  • Attribution — You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.
  • NonCommercial — You may not use the material for commercial purposes.
  • NoDerivatives — If you remix, transform, or build upon the material, you may not distribute the modified material.

License for the content created by course participants

Attribution-NonCommercial-NoDerivatives

You are free to:

  • Share — copy and redistribute the material in any medium or format

Under the following terms:

  • Attribution — You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.
  • NonCommercial — You may not use the material for commercial purposes.
  • NoDerivatives — If you remix, transform, or build upon the material, you may not distribute the modified material.
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